# Overview illness score for predicting [[Sepsis]] SOFA score = Sequential Organ Failure assessment - 6 organ systems scored according to their function - degree of organ support taken into account - used to analyse secondary endpoints in clinical trials ![[Pasted image 20240727155308.png]] parameters: - PaO2/FiO2 - plt count - bili - MAP - ionotropic req - GCS - Cr # Compare APACE and SOFA | | APACHE | SOFA | | -------------------------- | ------------------------------------------------------------------------------------------------------- | ------------------------------------------------------------------ | | Premise | ICU mortality depends on:<br>- pre-morbid health<br>- severity of illness<br>- pt physiological reserve | degree of organ dysfunction related to acute illness | | measured <br>parameters | 12 physiologic variables, GCS, age, chronic conditions | 6 domains of organ system f(x) | | measurement <br>collection | worse score in 24 hours | daily collection | | unique features | considers chronic illness, age, emergency admit, surgical vs. non-surg, arrest | considers use of organ system support eg vasopressors and dialysis | | score range | 0-71 | 0-24 | | mortality prediction | score 25 → mortality of 50% | does not predict mortality, but ↑ score a/w ↑ mortality | | prognostic value | poor predictor of individual outcome | monitor response to therapy using daily scores | # qSOFA - quick SOFA ("*HAT*") - presence of 2 or more of : - *H*ypotension: SBP ≤ 100 - *A*LOC: GCS <15 - *T*achyponea: RR ≥ 22 - and suspected infection, has risk of ↑ ICU stay or mortality - score ≥ 2 has 3-14-fold increase in in-hospital mortality