see: [Dunn's clotting factor replacement](x-devonthink-item://1BC22B6F-8634-47D6-8C7E-BE2827AD7DC9), [[cryoprecipitate]], [[Prothrombinex]], [[Massive blood transfusion]] > rh compatibility not required - use for acute reversal in active bleeding - ==initial dose of 1 unit if [[Prothrombinex]] is used== (150-300mL ) - 2-4 units if PCC not available (15mL/kg) - does not completely normalise levels of factor IX - Rh compatibility not required, but ==preferentially does need correct blood group== - [[Prothrombinex]] does NOT require blood group **Indications:** - single factor deficiency in [[Warfarin, DOAC, heparin reversal|warfarin]] - [[DIC]] - [[Thrombotic Thrombocytopaenic purpura|TTP]] - liver disease **Dose** - 15mL/kg - 2 units FFP will usually reverse therapeutic anticoagulation (INR 2-3) - 4-6 units usually required if INR > 5 - ​only one unit required if PCC used