# indications - acute ischaemic events - arterial gas embolism (eg from [[Diving injuries and Dysbarism]] with neuro or CVS impairment - decompression sickness - [[Central retinal artery occlusion|CRAO]] - sudden sensorineural deafness - gas toxicities: - [[carbon monoxide|CO]] - [[Cyanide]] - infections - clostridium gas gangrene - necrotising soft tissue infections - trauma: - crush injury + [[Compartment syndrome]] - acute thermal [[Burns]] # benefits - provides hyperoxygendation -- reverse tissue ischaemia - limit toxin production - bacteriostatic and bacteriocidal to obligate anaerobes - reduce tissue oedema -- induces vasoconstriction-mediated reductions of inflow without reducing outflow in posttraumatic tissue beds - stimulates angiogenesis - promotes osteogenesis - promotes wound healing - impaires B2integrin f(x) and the amplifying O2 gradients surrounding ischaemic wounds - diminishes inflammatory responses -- lowers monocyte chemokine synthesis - augments fibroblast replication - increases collagen formaiton - blunts ischemia-reperfusion injury to endothelial tissue - increases RBC flexibility - enhances leukocyte bactericidal activity -- improves neutrophil O2-dependent peroxidase activity - enhance abx transport into target bacteria - preserves intracellular ATP - terminades lipid peroxidation, obviating tissue destruction