see: [RCH - IVIG](https://www.rch.org.au/bloodtrans/about_blood_products/Intravenous_Immunoglobulin_Guideline/) Intravenous immunoglobulin (IVIg) is a solution of human plasma proteins and in particular IgG antibodies with a broad spectrum of antibody activity. IVIg is prepared from large pools of human plasma collected from several thousand blood donors. It’s used for patients who need replacement of antibodies and with autoimmune disorders. The mechanism that IVIG serves as an immunosuppressive is fairly theoretical, but it is used in situations where there is a dangerous and excessive host immune response ## Indications - [[Guillain-Barré syndrome]] - [[ITP]] - [[Kawasaki Disease]] - Toxic shock sepsis - some encephalopathy eg anti NMDA receptor - some [[haemolytic anaemia]]