#resus #tables #anaesthetics see: [[Airway]], [[Procedural sedation]] | agent | dose | onset (s) | duration (m) | situations to use | disadvantages | | ------------- | ---------------------------------- | --------- | ------------ | -------------------------------------------------------------------------------------------------- | ------------------------------------------------------------------------------------------- | | [[propofol]] | 1-2 mg/kg | 10 - 20 | 3 - 9 | - vomiting<br>- rapid onset/offset | - hypotension<br>- resp depression | | [[ketamine]] | 1-2 mg/kg | 30 - 40 | 5 - 10 | - hypovolaemia<br>- bronchospasm<br>- severe pain<br>- no resp depression<br>- less hypotension | - bronchorrhoea<br>- emergence<br>- longer duration of action<br>- mild ↑ ICP | | fentanyl | 100 - 400 mcg<br><br>3 - 10 mcg/kg | 60 -120 | | - *cardiogenic shock*<br>- reduce airway reflexes: avoid spike ICP<br>- relatively low hypotension | - resp depression<br>- chest wall rigidity<br>- no amnesia<br>- slower onset of peak effect | | [[midazolam]] | 0.05 - 0.3 mg/kg | 60 - 180 | 30 - 90 | - seizures<br>- amnesia<br>- minimal haemodynamic effects | - slow onset<br>- no analgesia | | thiopentone | 3 - 5 mg/kg | 30 - 40 | 10 - 30 | - head injury<br>- seizures<br>- ↑ ICP | - hypotension<br>- porphyria<br>- incompatible with rocuronium |