treatment for [[Cholinergic syndrome]] (eg [[organophosphates|organophosphate poisioning]] ) # Dose for cholinergic toxicity - to treat the muscarinic effects - **bradycardia** - **pulmonary secretions** **Endpoints**: - resolution of wheeze - HR > 80 BPM - Systolic BP > 80 > [!Dose] > - 1200mcg (50mcg/kg in paeds) > - double dose Q 5 minute until endpoints achieved > - infusion at 10-20% of the cumulative dose required to achieve adequate atropinization per hour Toxin:: [[Cholinergic syndrome]], [[organophosphates]]