see also: [[schizophrenia]] see: [Hayes' Clozapine](x-devonthink-item://E78534E8-BE8A-4488-8929-0F4748813A24) and [Clozapine toxicity](x-devonthink-item://D0EEA2F1-9A35-4B7D-89C6-03F92BE53DE6) [Austin Clozapine overdose](x-devonthink-item://DEDB277A-CCF2-4A4B-ADF6-1F68F5EB9338) > [!info] > Category: `=this.Category` > risk of *agranulocytosis*, neutropenia, myocarditis > - 2nd generation atypical antipsychotic - **4 life threatening reactions:** - [[febrile neutropenia|neutropenia]] - [[Myocarditis]] / cardiomyopathy - [[Neuroleptic Malignant Syndrome|NMS]] - lowered [[Seizures]] threshold Dose: tablets in 25mg - 200mg **Key points** - treat clozapine patients with fever as [[febrile neutropenia]] patient - in pts with persistent tachycardia at rest with other signs of heart failre, consider myocarditis or cardiomyopathy - risks of NMS not as high as first gen antipsychotics - rare to cause extrapyrmadil effects can also cause: - eosinophilia → discontinue if eosinophil count >3,000 mm3 - thrombocytopenia → cease if plts <50 - [[Anticholinergic toxicity|anticholinergic effects]] - macular degeneration (very rare)