see also: [[FFP]], [[Prothrombinex]] - [Dunn's clotting factor replacement](x-devonthink-item://1BC22B6F-8634-47D6-8C7E-BE2827AD7DC9) - often contained in second pack of a [[Massive blood transfusion]] - primarily used in Australia to replace **fibrinogen** b/c no widely available fibrinogen concentrate is available yet - use ABO compatible plasma when possible; Rh compatibility not required - *Group AB plasma* can be used for all ABO groups in an *emergency* - whole blood cryoprecipitate - 30-40 mL frozen plasma - 150 units factor VIII - fibrinogen 350 mg - factor XIII - vWF 260 IU - apheresis cryo - 60mL - 435 units VIII - fibrinogen 1g - XIII - vWF 730 IU # indications - bleeding and fibrinogen < 1.0 g/L - ==target should be >1.5-2 g/L in severe haemorrhage== - FIBTEM A5 ≤ 10mm on [[TEG, ROTEM, coagulation studies|ROTEM]] # Dose - adult - 5 bags of apherisis cryoprecipitate or 10 bags of whole blood cryoprecipitate - 20 units - will increase fibrinogen by 0.5-1 g/L - paeds - 1 aphresis bag/10kg body weight - 2 whole blood aphresis units/10kg body weight # administration - thaw prior to admin ; takes 30-60 min - 10ml/min - full dose in <1 hour