Toxin:: [[Sulfonylureas]] # Overview - Octreotide is a long-acting synthetic analogue of somatostatin. It is a specific antidote for sulfonylurea agents, as it suppresses insulin release from pancreatic cells # esophageal varices see [[Upper GI Bleed#Variceal bleeding treatment]] 50-100 mcg bolus, then infusion at 25-50 mcg/h for 48 hours # sulfonylurea overdose see [[Sulfonylureas]] > [!dose] > - 5mL/kg 10% glucose IV bolus, then 1-2mL/kg/hour 10% glucose IV infusion (paeds) > - infusion 1mcg/kg bolus then 1mcg/kg/hour infusion for 24 hours > - adults 50mcg IV bolus then 25mcg/hour infusion