see also: [[Massive blood transfusion]], [[Acute transfusion reactions]], [[Anaemia]], [[Blood transfusion (paeds)]] products: [[FFP]], [[cryoprecipitate]], [[thrombocytopaenia|platelets]] see: [Cochrane 2021 - Transfusion thresholds for guiding rbc transfusion](https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD002042.pub5/abstract?cookiesEnabled), [2023 AABB international guidelines](https://jamanetwork.com/journals/jama/article-abstract/2810754) ## PRBC transfusion threshold table ![[Pasted image 20250220140908.png]] | condition | threshold | rationale | | ------------------------------- | ---------------------------------------------------- | --------------------------------------------------------------------------------------------------------------------------------------- | | general | < 70 | | | [[Upper GI Bleed]] | - < 70 <br>- < 80 if existing cardiovascular disease | unless haemodynamically unstable | | [[traumatic brain injury\|TBI]] | <90 | [TRAIN study 2024](https://pubmed.ncbi.nlm.nih.gov/39382241/) | | ortho surgery | <80 | [Lifeblood](https://www.lifeblood.com.au/news-and-stories/health-professionals-news/red-blood-cell-transfusion-2023-aabb-international) | | pre-existing cardiac disease | <80 | | | trauma | | see [[Massive blood transfusion]] | | iron deficiency | | do not transfuse unless associated hemodynamic instability | | congenital heart disease | 70 - 90 | | | [[Sickle Cell Anaemia]] | < 100 | |