> - absolute neutrophil count ≤ 500 is severe neutropenia > - single temp 38.3 or sustained 38 is a fever > - susceptible to infection, even from their *own existing microbial flora* - due to underlying immunosuppression, neutropenic patients often do not manifest infectious signs or symptoms beyond fever **common sources:** - pneumonia - anorectal lesion - skin infection - pharyngitis - uti **Treatment** - pip-taz 4.5g IV Q6H - Gentamicin up to 7mg/kg IV if needing ICU - Meropenum 1g Q8H IV if known MDR organisms previously - consider vancomycin if prior MRSA