see also: [[Pulmonary Embolism]], [[DVT]] see: [Dunn - thrombophilia](x-devonthink-item://64AD698A-BAC4-4AC1-8CA5-CC8B4EA2FFE3) **acquired thrombophilia** - [[DIC]] - massive transfusion - major surgery or major trauma - OCP - pregnancy - antiphospholipid syndrome (lupus) - malignancy - hormone replacement therapy - hospitalisation - tamoxifen - hospitalisation - severe dehydration - past history of VTE - smoking **inherited thrombophilia** - Protein C and Protein S deficiencies - Factor V Leiden mutation (Activated Protein C resistance) - anti-thrombin III deficiency - hyper-homocysteinacemia ## investigations - FBC - clotting profile - fibrinogen - lupus anticoagulant - anti-cardiolipin Abs - Factor VIII levels - protein C - factor V mutation -