> acute febrile mosquito-borne viral illness that can lead to haemorrhagic fever. Named after the **jaundice** that occurs during toxic phase of the illness. > Has a vaccine - 90% of cases in Africa - 15% develop into toxic phase , of whom 20-50% die # signs/symptoms - malaise, backache, nausea/vomiting, headache, fever/chills, myalgia # Diagnostic testing - elevated AST/ALT - prolonged PT and PTT - thrombocytopenia - increased direct bilirubin with relatively nrmal ALP - Yellow fever-specific IgM and IgG can finfirm diagnosis - some cross-reactivity with other flaviviruses - because viremia only lasts for 3 days, *PCR is of limited value unless early in disease* # Treatment - supportive - paracetamol - avoid NSAIDs because of bleeding risks # Prevention - mosquito nets - S/c live-attenuated yellow fever **vaccine** if traveling to high risk areas