- most common lethal genetic disorder in white people - autosomal recessive - abnormality of all exocrine glands - causes thick sticky mucous to build up in lungs and digestive tract - recurrent resp infections - pancreatic exocrine deficiency - high seat chloride - most present by age 1 - neonatal SBO (**meconium ileus**, thick, stick, dark green) - failure to thrive - diarrhoea - recurrent resp infecitons - prolonged neontal jaundice - dehydration with hypochloremic alkalosis - diabetes - rectal prolapse # Resp emergencies - cor pulmonale (right heart failure - haemoptysis - pneumothorax - resp failure # GI emergencies - [[neonatal bowel obstruction#meconium ileus]] - [[Intussusception]] # other - [[dehydration]] - electrolyte depletion a/w GI losses and heavy sweating