see also: [[Weakness]], [[peripheral nerve disorders]] | Central | peripheral | | ---------------------- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- | | space-occupying lesion | myocardial ischaemia | | [[Stroke\|CVA]] | peripheral neuropathy (DM, EtOH, B12/thiamine def | | [[Headache\|migraine]] | syringomyelia (spinothalamic tract damage) | | [[Multiple Sclerosis]] | cervical/thoracic nerve root lesion (C5 -T2 posterior root lesions (eg spondylosis or herniated disk | | | brachial plexus lesion (saturday night palsy | | | thoracic outlet syndrome (or thoracic aortic aneurysm) | | | MS | | | peripheral vascular disease | | | lyme disease | | | leprosy | | | chemotherapy or HAART | | | *sensory neuronopathies* (dorsal root ganglionopathies) -- eg HSV or [[Herpes zoster\|Shingles]], paraneoplastic, primary biliary cirrhosis, Sjogren's , toxin-induced (pyridoxine/[B6](https://theconversation.com/too-much-vitamin-b6-can-be-toxic-3-symptoms-to-watch-out-for-260400), mercury, platinum, [[Lead]] |