Toxin:: [[Opiate overdose]] - 400 mcg in 10mL syringe (40mcg/mL) - increasing dose every minute 1 mL --> 2mL --> 3mL (40 mcg, 80mcg, 120 mcg) up to total dose of 2000mcg * If no IV, then 800mcg IM  infusion: 2/3 dose needed to achieve respiration per hour  **therepeutic endpoint**: SpO2 >92% in opiate user; awake in opiate-nieve  observe for re-sedation at least 2 hours after last bolus dose or 6 hours post infusion